Publications

Dopamine D1 or D3 receptor modulators prevent morphine tolerance and reduce opioid withdrawal symptoms.

Rodgers HM, Lim SA, Yow J, Dinkins ML, Patton R, Clemens S, Brewer KL. Pharmacol Biochem Behav. 2020 Jul;194:172935. doi: 10.1016/j.pbb.2020.172935. Ep

Dopamine D1 and D3 receptor modulators restore morphine analgesia and prevent opioid preference in a model of neuropathic pain.

Rodgers HM, Yow J, Evans E, Clemens S, Brewer KL.  Neuroscience. 2019 May 15;406:376-388. doi: 10.1016/j.neuroscience.2019.03.034. Epub 2019 Mar 23. PMID: 30910641. 

Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome.

Meneely S, Dinkins ML, Kassai M, Lyu S, Liu Y, Lin CT, Brewer K, Li Y, Clemens S. Front Behav Neurosci. 2018 Sep 4;12:199. doi: 10.3389/fnbeh.2018.00199. PMID: 30233336; PMCID: PMC6131574. 

Morphine responsiveness to thermal pain stimuli is aging-associated and mediated by dopamine D1 and D3 receptor interactions.

Samir S, Yllanes AP, Lallemand P, Brewer KL, Clemens S. Neuroscience. 2017 May 4;349:87-97. doi: 10.1016/j.neuroscience.2017.02.042. Epub 2017 Feb 28. PMID: 28257894; PMCID: PMC5416409. 

Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord.

Brewer KL, Baran CA, Whitfield BR, Jensen AM, Clemens S. Front Neural Circuits. 2014 Jun 11;8:62. doi: 10.3389/fncir.2014.00062. PMID: 24966815; PMCID: PMC4052813. 

Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse.

Keeler BE, Baran CA, Brewer KL, Clemens S. Exp Neurol. 2012 Dec;238(2):273-83. doi: 10.1016/j.expneurol.2012.09.002. Epub 2012 Sep 17. PMID: 22995602.

A novel opioid/pramipexole combination treatment for the management of acute pain: a pilot study.

 Cara Girardi, Joseph Duronio, Ryan Patton, Kevin O'Brien, Stefan Clemens, Kori L Brewer. Front. Pain Res., 2024 Sept 4. PMID: 39411383 PMCID: PMC11476544 DOI: 10.3389/fpain.2024.1422298