Publications

Rodgers HM, Lim SA, Yow J, Dinkins ML, Patton R, Clemens S, Brewer KL. Dopamine D1 or D3 receptor modulators prevent morphine tolerance and reduce opioid withdrawal symptoms. Pharmacol Biochem Behav. 2020 Jul;194:172935. doi: 10.1016/j.pbb.2020.172935. Epub 2020 Apr 23. PMID: 32335101. 

Rodgers HM, Yow J, Evans E, Clemens S, Brewer KL. Dopamine D1 and D3 receptor modulators restore morphine analgesia and prevent opioid preference in a model of neuropathic pain. Neuroscience. 2019 May 15;406:376-388. doi: 10.1016/j.neuroscience.2019.03.034. Epub 2019 Mar 23. PMID: 30910641. 

Meneely S, Dinkins ML, Kassai M, Lyu S, Liu Y, Lin CT, Brewer K, Li Y, Clemens S. Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome. Front Behav Neurosci. 2018 Sep 4;12:199. doi: 10.3389/fnbeh.2018.00199. PMID: 30233336; PMCID: PMC6131574. 

Samir S, Yllanes AP, Lallemand P, Brewer KL, Clemens S. Morphine responsiveness to thermal pain stimuli is aging-associated and mediated by dopamine D1 and D3 receptor interactions. Neuroscience. 2017 May 4;349:87-97. doi: 10.1016/j.neuroscience.2017.02.042. Epub 2017 Feb 28. PMID: 28257894; PMCID: PMC5416409. 

Brewer KL, Baran CA, Whitfield BR, Jensen AM, Clemens S. Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. Front Neural Circuits. 2014 Jun 11;8:62. doi: 10.3389/fncir.2014.00062. PMID: 24966815; PMCID: PMC4052813. 

Keeler BE, Baran CA, Brewer KL, Clemens S. Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse. Exp Neurol. 2012 Dec;238(2):273-83. doi: 10.1016/j.expneurol.2012.09.002. Epub 2012 Sep 17. PMID: 22995602.